Longitudinal bidirectional association of biological aging acceleration with depressive symptoms in mid-to-late life: evidence from the China Health and Retirement Longitudinal Study.

In the fully adjusted model (model 4), participants classified as biologically older at baseline, compared to those classified as biologically younger, had a 20.2% increased risk (OR = 1.202, 95% CI: 1.020, 1.417) of developing depression. In the stratification analyses, a marginally statistically significant modification effect for sex was identified in the longitudinal association between baseline biological aging acceleration and later depression.

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