Hesperidin Attenuates H₂O₂-Induced Neurotoxicity via Modulation of Inflammatory Pathways and MMP Activity in Differentiated SH-SY5Y Cells: In Vitro and In Silico Models.

Although the IL‐6 mRNA expression levels showed a decreasing trend in all treatment groups compared to the H 2 O 2 group, the reduction was not statistically significant ( p > 0.05); however, IL‐6 protein levels were significantly decreased across the treatment groups ( p < 0.01). 3.5 Hesperidin Modulates Key Inflammatory and MMP Genes The effect of Hesperidin on the gene expression of NF‐κB and COX‐2 , two key mediators of neuroinflammation, was analyzed using the RT‐qPCR method.

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