Local Versus Systemic Antibiotics for Diabetic Foot Infection-A Systematic Review and Meta-Analysis.

J Diabetes · 2026 · PMC12973258 · PMID 41804939

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failed to reach significanceno p-value reported

Combination antibiotics were associated with increased clinical cure rates compared with systemic antibiotics alone (OR 2.08; 95% CI 1.30–3.35; p < 0.05) and faster healing times (Mean −9.8 days; 95% CI −15.1 to −4.4; p < 0.05); however, results failed to reach significance when looking at randomized studies alone.

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