SRSF2 mutations drive daunorubicin resistance in acute myeloid leukemia via THBS1 stabilization.

J Exp Clin Cancer Res · 2026 · PMC12973616 · PMID 41618430

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an increasing trendno p-value reported

In contrast, SRSF2 mut xenografts displayed a selective response pattern, showing a reduction in only splenic infiltration while maintaining persistent hepatic involvement (with an increasing trend) and unaltered bone marrow infiltration posttreatment.

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