Barely Significant
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Protective Role of Metformin in Glaucoma: Prospective Cohort Study, Meta-Analysis, and Drug-Target Mendelian Randomization.

Ophthalmol Sci · 2026 · PMC12973693 · PMID 41816092

Europe PMCDOI
1
hedged sentence
0.0540
closest p · 1.1× alpha
0.0540
boldest claim

The sentences

a nonsignificant trendP = 0.054so close (0.05 < p ≤ 0.1)
In cross-sectional studies, metformin showed a nonsignificant trend toward reduced glaucoma risk (OR, 0.31; 95% CI, 0.10–1.02; P = 0.054), with substantial heterogeneity (I 2 = 87.8%, Q = 16.38; P < 0.001) ( Fig 2 ).

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