Association of Multiple-trait Polygenic Risk Score with Obesity and Cardiometabolic Diseases in Korean Population.

As shown in Table S17 , both the target disease PRS and obesity classification were highly significant predictors in all regression models.

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Mediation analyses revealed that the total effects of obesity PRSs on T2D and CVD were partially significant and primarily driven by the indirect effects through obesity.

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Transethnic genetic correlation analyses between the EAS meta-analyses and the REP3 NHW dataset showed strong correlations with moderate levels of general obesity (0.82, P = 4.01 × 10 −3 ) and abdominal obesity (0.72, P = 6.37 × 10 −4 ), suggesting that genetic signals relevant to obesity in Koreans may be significant in NHW populations.

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