Nighttime-restricted feeding disrupts spermatogenesis in mice via gut microbiota-derived KYNA homeostasis.

We further performed a cross-Correlation-Analysis with 16S rRNA sequencing and metabolomics data, showing highly significant correlations ( p < 0.01) between KYNA levels in cecal contents and multiple bacterial taxonomic units ( Desulfovibrionales , Mucispirillaceae ) that were enriched in NRF mice (Fig. 6a ). suggesting KYNA KYNA is produced by abnormal enrichment of gut microbiota in NRF mice.

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Consistent with this, we found a decreasing trend in sperm concentration and motility in the NRF group (Fig. 1 e, 1f).

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