Of note, Gpc3 mRNA levels showed a decreasing trend in the brain, but not in the pancreas, of mutant mice ( S3B Fig ).
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Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity.
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When using the same injection protocol while maintaining the mice on CD ( Fig 5D ), an increasing trend in body weight gain was also observed in mutant mice, though statistical significance was not reached ( Fig 5E ).