Single-cell resolution of an open chromatin signature in persister tumor cells.

Cell Rep · 2026 · PMC12978573 · PMID 41485222

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a decreasing trendno p-value reported

Global changes in open chromatin (cut sites) could be characterized by two main observations: (1) a decreasing trend in the chromatin accessibility of immune cells from FT to naive tumors and then to NACT tumors and (2) a general increasing trend in open chromatin sites in endothelial cells, fibroblasts, and epithelial cells from naive tumors to NACT tumors ( Figure S2C ).

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