Partial breast irradiation versus whole breast irradiation after breast-conserving surgery in early-stage breast cancer: a systematic review.

Oncologist · 2026 · PMC12979050 · PMID 41701174

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compared PBI with 3D-CRT BID versus WBI; PBI caused higher acute and late toxicity, worse cosmetic outcomes, and a nonsignificant trend toward higher recurrence, but OS and DFS were similar. 9 The TARGIT-A trial by Vaidya et al. compared APBI with RIO versus WBI; PBI showed lower acute/late toxicity and fewer nonbreast cancer events, but higher local recurrence (3.3% vs 1.3%).

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