Barely Significant
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Efficacy and Safety of Conventional and Biologic Therapies in Prurigo Nodularis: A Systematic Review and Meta-Analysis.

Int J Dermatol · 2026 · PMC12979244 · PMID 41495913

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highly significantno p-value reported
Moreover, based on our quantitative analysis, findings indicate that dupilumab not only alleviates pruritus but also produces clinically meaningful improvements in quality of life, as evidenced by substantial reductions in DLQI scores, where mean improvements exceeding the 10‐point threshold are considered highly significant.

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