When we analyzed the effects on the growth attenuation of the COs infected with VR1814 strain, antiviral treatment showed an overall trend of rescue of organoid size compared to vehicle-treated infected COs, although statistical significance was obtained only for LTV-treated, infected COs (Fig. 6 B).
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Letermovir shows antiviral and neuroprotective effects in differentiating neurons and cerebral organoids mimicking human developing brain.
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