Evaluation of genetic variation in tumor suppressor miRNA encoding and their target genes in breast cancer; focus on miRNA interaction and expression analysis.

Expression patterns of hsa-miR-181c and hsa-let-7c KRAS expression exhibited a highly significant, genotype-driven escalation across rs712 and rs9266 variants (p < 0.0001), revealing a clear molecular gradient: WT carriers maintained minimal KRAS expression, whereas HT patients displayed a dramatic surge the highest observed followed by a substantial, though slightly lower, increase in HM.

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