Integrative machine learning identifies a TEAD4-driven endothelial program shaping drug sensitivity and microvascular invasion in HCC.

J Transl Med · 2026 · PMC12983702 · PMID 41664193

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a mild trendno p-value reported

This observation aligns with previous reports linking YAP activation to poor prognosis [ 43 , 44 ] but further specifies cell-type specificity: Hippo activation is most pronounced in endothelial cells, whereas fibroblasts exhibit only a mild trend.

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