COG5 deficiency disrupts cellular copper homeostasis and underlies the impaired mitochondrial OXPHOS function.

It is curious that copper levels in the add-back are much closer to those in the knock-out than the parental control, and the normalization to cell number is also not ideal because it can be confounded by differences in cell size, which might be significant since the knock-out cells are likely quite sick according to a variety of presented data (e.g., electron microscopy in Fig S1G).

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