Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.

Using a strict linkage disequilibrium (LD)-based definition of independence ( Methods ), this meta-analysis (81,718 cases, 732,951 controls) produced a total of 417 independent genetic associations outside the major histocompatibility complex (MHC; Supplementary Table 1 ) and numerous highly significant MHC associations centered at previously reported common variants spanning the DRB1 – DQA1 – DQB1 locus 5 .

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