Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice.

Furthermore, simultaneous knockdown of all three Akt isoforms resulted in a significant reduction in cyclin D1 and Myc (Figure S1D-E) while Axin2 level showed a decreasing trend, compared to the vehicle (Figure S1F).

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We observed an increasing trend in Caspase-3/7 activity in iCRT3-treated cells following 6 h treatment, while MK-2206 treatment significantly increased caspase activity, compared to the vehicle (Fig. 1 D).

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