an increasing trendp = 0.11
However, we observed the worsening of the disease as both LV end-systolic (ESV) and -diastolic volumes (EDV) showed an increasing trend (ESV: 27 ± 8 mL vs. 45 ± 8 mL, p = 0.11; EDV: 36 ± 9 mL vs. 54 ± 6 mL, p = 0.25), indicating that the protocol affected the ventricular morphology ( Figures 2a,b ).