Targeting Protein Tyrosine Phosphatase 1B (PTP1B) to Improve Insulin Sensitivity Using Indole-Fused Glycyrrhetinic Acid Conjugates with Amino Acids.

ACS Med Chem Lett · 2026 · PMC12989875 · PMID 41847642

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a favorable trendno p-value reported

The predicted aqueous solubility shows a favorable trend when Gly (−9.21) or Arg (−9.22) is added at C30 of compound 4 (−9.48).

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