Levetiracetam versus phenobarbital as first-line therapy for neonatal seizures: a comprehensive systematic review and meta-analysis with meta-regression of 26 studies involving 9,854 neonates.

[ 51 ] concluded that there was no significant difference in seizure control efficacy between LEV and PB(with high heterogeneity), but reported that LEV was associated with significantly lower rates of hypotension, respiratory depression, and depressed sensorium, and a possible trend toward better short-term neurodevelopmental outcome—in only one RCT with pure cohorts.

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