AQbD-driven development of a green RP-HPLC method for nirogacestat with LC-MS structural elucidation.

BMC Chem · 2026 · PMC12990555 · PMID 41668179

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closest p · 0.0× alpha

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highly significantp < 0.0001actually significant

All models were highly significant ( p < 0.0001), with high F-values (R1 = 583.16, R2 = 695.27, R3 = 289.65, R4 = 46.85, R5 = 215.85, and R6 = 187.61 for theoretical plates) and non-significant lack-of-fit tests, indicating strong predictive capability.

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