Bafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex.

PLoS Pathog · 2026 · PMC12991224 · PMID 41838682

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an increasing trendno p-value reported

spiralis showed an increasing trend after treatment with low concentration of BafA1, the loss of the auxiliary transport function due to the inhibition of Ts -ATP6V0C activity still led to the inhibition of the worm’s vitality.

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