Total and live birth prevalence of singleton pregnancies with Down's syndrome in Scotland between 2000 and 2021: a population-based study.

Piecewise regression estimates provide no evidence of a time trend between 2000 and 2012 (PRR 1.00, 95% CI 0.99, 1.02; p = 0.99), whereas there was an increasing trend in TB prevalence of DS between 2013 and 2015 (PRR 1.16, 95% CI 1.07, 1.26; p < 0.001) and a decreasing trend between 2016 and 2021 (PRR = 0.94, 95% CI 0.92, 0.97; p < 0.001) ( Fig. 2 , Table 2 ).

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Piecewise regression estimates provide no evidence of a time trend between 2000 and 2012 (PRR 1.00, 95% CI 0.99, 1.02; p = 0.99), whereas there was an increasing trend in TB prevalence of DS between 2013 and 2015 (PRR 1.16, 95% CI 1.07, 1.26; p < 0.001) and a decreasing trend between 2016 and 2021 (PRR = 0.94, 95% CI 0.92, 0.97; p < 0.001) ( Fig. 2 , Table 2 ).

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This could be explained by the highly significant linear relationship (χ 2 = 130.73, p < 0.001) between SIMD and maternal age, with maternal age increasing as SIMD increased: SIMD 1 and SIMD 2 have more younger mothers with a pregnancy with DS (18%, 15%, respectively) compared to SIMD 4 and SIMD 5 (5% and 2%, respectively) ( Appendix 1 , Table S8 ).

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