T cell-specific HIF-2α attenuates colitis by antagonizing notch-driven Th2 differentiations.

Front Immunol · 2026 · PMC12992320 · PMID 41853284

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did not achieve significanceno p-value reported

While trended increases in the vast majority of Th1-related genes did not achieve significance, upward trends for Il1a, Il1b, Il18rap, and Rela ( Figure 3C ), together with marked induction of Tlr4 in Toll-like receptor signaling ( Figure 3D ), imply broader innate immune activation.

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