Misconceptions of Traits to Predict Response to Inhaled Corticosteroid and Bronchodilator Therapies in Asthma: A Narrative Review.

Pulm Ther · 2026 · PMC12992740 · PMID 41324781

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a numerical trendno p-value reported

In CAPTAIN prespecified analyses [ 27 ], there was a numerical trend for a greater reduction in moderate/severe attacks among ex-smokers versus patients without smoking history after adding UMEC to FF/VI, although, as with other studies, the number of ex-smokers was low versus the other subgroups, and smoking history was limited (i.e., < 10 pack years).

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a possible trendno p-value reported

Addition of UMEC to FF/VI resulted in improvements in trough FEV 1 and FEV 1 3 h post dose (post hoc analysis) in both subgroup populations (consistent across FF 100 μg- and FF 200 μg-containing therapies) and attack rates (FF 100 μg-containing therapies), with a possible trend for greater numerical improvements in these outcomes in patients without a history of severe attacks (prespecified analysis).

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