Relationships Between Polygenic Scores for Psychopathology and Observed Psychopathology Are Mediated by Cognitive Control and Reward Sensitivity Pathways: Insights From the ABCD Study.

Biol Psychiatry Glob Open Sci · 2026 · PMC12993133 · PMID 41852603

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marginally significantno p-value reported

Although the indirect effect from the internalizing PGS to sensation seeking was nonsignificant in the simple regression, it became marginally significant and negative in multiple regression, in contrast to the positive association observed for the addiction PGS.

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