The TNFR superfamily member Fn14 impacts immunity and survival in experimental gliomas and response to immune checkpoint inhibitor therapy in glioblastoma patients.

In contrast, an increasing trend in the relative frequency of both CTLA-4+ CD8+ T-cells ( Figure 5F ) and PD-1+ CD8+ T-cells ( Figure 5H ) was observed in Fn14-/KO CT-2A tumors compared to Fn14+/WT controls.

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