DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling.

Signal Transduct Target Ther · 2026 · PMC12996283 · PMID 41844571

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an increasing trendno p-value reported

Blockade of SHP1 and DUSP6 led to significantly increased AP-1 activation in CAR-Jurkat AP-1 reporter cells stimulated with CD58 KO tumor cells, whereas PTPN7 blockade, although not significantly, resulted in an increasing trend (Fig. 4h ).

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