Integrative multi-omics analysis reveals CXCL10-driven inflammation and TREM2 + macrophage-plasma cell survival niche as hallmarks of late-stage rheumatoid arthritis.

Arthritis Res Ther · 2026 · PMC12997883 · PMID 41680947

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borderline significanceP = 0.050actually significant

7 A), IFIH1 and ISG15 showed no significant association with late-stage RA, while CXCL10 demonstrated borderline significance (OR = 2.170, P = 0.050).

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