Combinatorial Anti-Mitotic Activity of Loratadine/5-Fluorouracil Loaded Zein Tannic Acid Nanoparticles in Breast Cancer Therapy: In silico, in vitro and Cell Studies.

Int J Nanomedicine · 2026 · PMC12998966 · PMID 41858579

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

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highly significantp < 0.0001actually significant

In addition, the quadratic term X 3 2 (LOR2) was highly significant ( p < 0.0001), along with a large negative coefficient (−272.987), confirming the strong nonlinear suppressive effect of higher LOR concentrations on the nanoparticle size.

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