Notably, the treatment of ferroptosis inhibitor Ferrostatin-1 (Fer-1), but not necrosis inhibitor Necrostatin-1 (Nec-1) or apoptosis inhibitor Z-VAD-FMK (Z-VAD), extremely significant rescued cell death of WT CD8 + T cells upon TC-1-stimulation (Supplementary Fig.
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STING synergizes with TOX suppressing HO-1 expression to trigger ferroptosis in tumor-infiltrating CD8+ T cell and immunotherapy resistance.
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