highly significantP <.001
The model showed a significant decrease during the first segment (weeks 1-6: B=−0.02, 95% CI −0.02 to −0.01; P <.001), followed by a larger and highly significant decrease during the second segment (weeks 6-10: B=−0.08, 95% CI −0.10 to −0.06; P <.001; Figure 1 ).