An Ad5-Based COVID-19 Vaccine Encoding SARS-CoV-2 Spike Glycoprotein Induces Measurable Antibody and Cytokine Responses in Mice.

ELISA‐based quantification of IFN‐γ in splenocyte culture supernatants confirmed a highly significant increase in cytokine secretion across all Ad5Spike‐vaccinated groups at both day 30 and day 90 compared to controls (Figure 4A ).

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