However, the Study of Mirtazapine for Agitated Behaviors in Dementia (SYMBAD) trial (n = 204) found no significant benefit over placebo for agitation in AD and noted a nonsignificant trend toward higher mortality at 16 weeks. 70 Caution is advised when prescribing mirtazapine for this indication.
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Pharmacological management of agitation in dementia: An evidence-based review with expert consensus.
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