Within the serum of Wilson patients, CP activity was significantly reduced, 57 while within the serum of patients with gastrointestina cancers, CP levels showed an elevated trend. 58 Copper ions can act as one of the catalysts, catalyzing the overexpression of hydrogen peroxide to mediate the Fenton reaction, generating hydroxyl radicals by which tumor cells are killed. 59 Copper is one of the essential trace elements, which is involved in a variety of key physiological processes within cells and can regulate key components of the tumor microenvironment.
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Research Progress on Copper Metabolism, Cuprotosis, and Their Regulatory Mechanism in Tumor Diagnosis and Treatment.
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