Spatial omics study reveals molecular-cellular dynamics of tumor ecosystem in esophageal squamous-cell carcinoma initiation and progression.

Cell Rep Med · 2026 · PMC13006417 · PMID 41791392

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an increasing trendno p-value reported

A substantial decrease in mast cells, neutrophils, and endothelial cells and an increasing trend in macrophages were observed in the advanced stage ( Figures 6 B and S7 A).

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a decreasing trendno p-value reported

Furthermore, NC showed a decreasing trend in ESPL but increased in ESCC ( Figure 3 C).

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