borderline significantP = 0.058
After testing the enrichment in the 3D hotspot using a GLMM with antibody counts as outcome, a borderline significant enrichment in case samples was observed in the ENDIA cohort (RR 5.75; 95% CI 0.94, 35.16; P = 0.058) ( Supplementary Table 3 B ), although the CIs were wide.