Rare germline variants contribute to glioma predisposition: Whole-genome analysis of a regional cohort of glioma patients.

Neurooncol Adv · 2026 · PMC13007284 · PMID 41878702

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

borderline significantP = .07so close (0.05 < p ≤ 0.1)

DNMT3A showed a borderline significant ( P = .07) excess burden of pLoF variants among glioma cases and SMAD4 ( P = .06) burden of missense + pLoF variants ( Table S7 ).

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