Perillaldehyde combined with domiphen: synergistic bactericidal and anti-biofilm activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>.

Furthermore, this combined treatment achieved a reduction greater than 102 CFU/mL relative to either agent administered alone, exhibiting a highly significant difference ( P < 0.01). 3.3.3 Using drug combination for removing bacterial biofilms on rubber surfaces On rubber surfaces, the combination of perillaldehyde (1 μL/mL) and domiphen (1 μg/mL) significantly reduced viable S. aureus biofilm counts by approximately 10 2 CFU/mL compared to the control ( Figure 3C , P< 0.01), corresponding to a 30.13% eradication efficiency.

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