highly significantP < 0.01
P-value thresholds were defined as follows: not significant (ns, P > 0.05), statistically significant (*, P < 0.05), highly significant (**, P < 0.01), and extremely significant (***, P < 0.001).
P-value thresholds were defined as follows: not significant (ns, P > 0.05), statistically significant (*, P < 0.05), highly significant (**, P < 0.01), and extremely significant (***, P < 0.001).