Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system.

PLoS Negl Trop Dis · 2026 · PMC13012625 · PMID 41843614

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highly significantno p-value reported

Also, again note that highly significant overlaps can be either higher or lower than the randomly expected genome-wide background rate.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.