Spatiotemporal heterogeneity and multiscale social influencing factors of syphilis in the mainland of China, 2005-2022.

X 1 had a highly significant positive impact during 2005–2010 (β 1 = 0.836, p < 0.01), weakened and became statistically insignificant during 2011–2019, and then regained a significant positive effect in 2020–2022 (β 3 = 0.530, p < 0.01), suggesting that post-COVID economic recovery had notably contributed to the rise in syphilis incidence.

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An APC or AAPC greater than 0 indicates an increasing trend, while a value less than 0 indicates a decreasing trend.

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The sigmas for the three periods were 0.3126, 0.3834, and 0.5603, respectively, demonstrating a decreasing trend in the fitting performance.

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