Exposure of endothelial cells to doxorubicin inhibits extracellular matrix production by dermal fibroblasts in a paracrine manner.

Toxicol Sci · 2026 · PMC13017147 · PMID 41776828

Europe PMC DOI

hedged sentence

0.0644

closest p · 1.3× alpha

0.0644

boldest claim

The sentences

borderline significantP = 0.0644so close (0.05 < p ≤ 0.1)

CM Dox10 -treatment resulted in a significant 3.2 ± 1.9-fold increase in MMP1 transcription ( P < 0.05), and a borderline significant 2.4 ± 1.6-fold increase in MMP9 transcription ( P = 0.0644) compared with CM DMSO10 .

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