The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives.

Front Endocrinol (Lausanne) · 2026 · PMC13017269 · PMID 41907544

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marginally significantno p-value reported

Using an ad libitum energy intake model, MK-0493 was associated with a small and marginally significant reduction in total 24-hour energy intake, whereas 30 mg of sibutramine (positive control) was associated with a significant reduction in total 24-hour energy intake ( 48 ).

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