Design, synthesis, molecular docking and cytotoxic evaluation of novel pyrimidine-based sulfonamide derivatives as potent anticancer agents: SAR insights and biological profiling.

Sci Rep · 2026 · PMC13018296 · PMID 41876606

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extremely significantno p-value reported

With IC 50 values ranging from 7.4 to 10.2 μg/mL against HepG2 and 8.2 to 10.0 μg/mL against MCF-7, compounds 18 , 21 , 23 , and 24 showed extremely significant anticancer activity, nearly matching the potency of the reference medication 5-fluorouracil.

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