Barely Significant
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Bactrim Efficacy in Preventing Infections in Glomerular Diseases Receiving Rituximab.

Kidney Med · 2026 · PMC13019557 · PMID 41908608

2
hedged sentences
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

narrowly missed statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)
Independent adjustment for age and sex showed a similar protective trend, though these results narrowly missed statistical significance (HR, 0.59; 95% CI, 0.35-1.02 and HR, 0.59; 95% CI, 0.34-1.03, respectively; P = 0.06 for both).

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marginally insignificantno p-value reported
This suggests that the observed benefit of Bactrim is likely robust across key demographic and clinical factors, although the marginally insignificant results in some of the models indicate the need for cautious interpretation and further validation in larger cohorts.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.