Saline vs Contrast for Optical Coherence Tomography During Percutaneous Coronary Intervention: A Prospective Multicenter Study.

The consistently negative regression coefficients (β = −0.041 to −0.083, P ≥ 0.058) indicate a nonsignificant trend where differences become more negative with increasing vessel size, suggesting saline measurements may be relatively smaller in larger vessels—potentially due to incomplete blood clearance or differential pressure effects in compliant arteries.

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