Barely Significant
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Mitoregulin supports mitochondrial membrane integrity and protects against cardiac ischaemia-reperfusion injury.

Cardiovasc Res · 2026 · PMC13019689 · PMID 41555203

Europe PMCDOI
1
hedged sentence
0.2000
closest p · 4.0× alpha
0.2000
boldest claim

The sentences

a weak trendP < 0.2not close (p > 0.1)
Acute Mtln-KO mitochondria showed additional signs of ROS-induced membrane damage, with lipidomics data indicating a weak trend towards increases in monolysocardiolipin (MLCL 18:2_18:2_18:2, P < 0.2), and notably, follow-up auxiliary analyses revealed that MLCL/CL ratios are significantly increased by ∼20% in acute Mtln-cKO samples ( Figure 5 F , P = 0.015, representing the ‘top hit’, most significant P -value in this lipidomics dataset).

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