Disrupted autophagy overactivates TBK1 and results in mitotic defects promoting chromosomal instability.

In addition, our recent phosphoproteomic screen uncovered two TBK1-dependent sites on ATG9A at S654 and S656 during mitosis that were highly significant across tested conditions (genotype and pharmacological inhibition of TBK1) [ 34 ] ( Figure 4A ).

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