Characterising processing conditions that artifactually bias human brain tissue transcriptomes.

Regression analysis of PC1 scores confirmed that age had no significant impact on sample distribution (coefficient = 0.28; p = 0.43), whereas group was the dominant determinant of separation, with a strong and highly significant coefficient of 81.47 ( p = 7.86 × 10−7) (Supplementary Fig. 2E ).

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